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KMID : 1098420080160030173
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 3 p.173 ~ p.182
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Biological Activity Investigation, and Phenol Compounds Isolation from Barks of Prunus Sargentii R.
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Park Jung-Mi
An Bong-Jeun
Lee Jin-Young
Park Tae-Soon
Choi Kyung-Im
Kwon O-Jun
Cho Young-Je
Park Gun-Hye
Park Kang-Soo
Kim Tae-Hoon
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Abstract
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Prunus sargentii of Rosaceae familiy, has been reported to have radical scavenging activity and anti-inflammatory effect. On these facts, this research was conducted to evaluate pharmaceutical activities of the bark extracts P. sargentii. Free radical scavenging activities of fraction (Fr) -510 isolated from P. sargentii was higher than 80% respectively at 10ppm. The superoxide dismutase (SOD)-like activity of Fr-5, 9 were about 97, 84%, respectively at 1,000 ppm. Xanthine oxidase inhibitory effect of Fr-9, 10 were about 75, 78%, respectively at 1,000 ppm. The tyrosinase inhibitory effect related to skin-whitening was 72, 68% in Fr-2, 9 isolated from Prunus sargentii R. at 1,000 ppm. Hyaluronidase inhibition activity related to the anti-inflammation effect was 98% for Fr-8 at 500 ppm. Isolation of the methanol soluble fraction from P. sargentii yielded two major phenol compounds, (-)-epicatechin and taxifolin. The structure of the compound was certainly determined by chemical analyses, as well as NMR and Mass spectroscopy. The present study was carried out in a search for new cosmetic material from the bark from P. sargentii. and, (-)-epicatechin and taxifolin were isolated as active principles. So P. sargentii R. methanolic extracts may be used for the cosmetic material.
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KEYWORD
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Prunus sargentii R., Biological activities, Epicatechin, Taxifolin
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